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. 2020 Nov 26;12(12):3536. doi: 10.3390/cancers12123536

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of tTF-NGR on normal (non-athymic) CD-1 or BALB/C mice. (A) Lethality given as percentage of mice treated (1 day observation period) for normal (non-athymic) CD-1 or BALB/C mice (2–5 months old) upon i.v. injection of tTF-NGR at the doses of 0.0, 1.5, 3.0, 5.0, 6.0, 8.0, and 10.0 mg tTF-NGR/kg body weight. LD10 (lethal dose for 10 % of the animals treated) was 5.0 mg/kg or 15.0 mg tTF-NGR/m² b.s.a. (B) H & E staining of lungs of mice that died upon treatment with toxic doses of tTF-NGR. Blood vessels are thrombosed (arrows).

Effects of tTF-NGR on normal (non-athymic) CD-1 or BALB/C mice. (A) Lethality given as percentage of mice treated (1 day observation period) for normal (non-athymic) CD-1 or BALB/C mice (2–5 months old) upon i.v. injection of tTF-NGR at the doses of 0.0, 1.5, 3.0, 5.0, 6.0, 8.0, and 10.0 mg tTF-NGR/kg body weight. LD10 (lethal dose for 10 % of the animals treated) was 5.0 mg/kg or 15.0 mg tTF-NGR/m² b.s.a. (B) H & E staining of lungs of mice that died upon treatment with toxic doses of tTF-NGR. Blood vessels are thrombosed (arrows).