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Representative HPLC chromatogram of cabozantinib metabolites formed in the presence of NADPH (blue line) and without NADPH (control, black line). M1—monohydroxy cabozantinib; M2—desmethyl cabozantinib; M3—cabozantinib N-oxide (A). Detailed mass spectrum and structure (insert) of cabozantinib (B), desmethyl cabozantinib (C), monohydroxy cabozantinib (D) and cabozantinib N-oxide (E).
