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Enzyme kinetics of cabozantinib oxidation by CYP3A4 (A–C) and CYP3A4 in the presence of cytochrome b5 (D–F) to monohydroxy cabozantinib (A,D), desmethyl cabozantinib (B,E) and cabozantinib N-oxide (C,F). Values represent means ± SD of three independent in vitro incubations (n = 3).
