Table 2.

Correlation coefficient (r) among CYP- and FMO-linked catalytic activity and amounts of cabozantinib metabolites formed in microsomes.

	Total CYPs	CYP1A2	CYP2A6	CYP2B6	CYP2C8	CYP2C9	CYP2C19	CYP2D6	CYP2E1	CYP3A4	CYP4A11	FMO
M1	0.705 *	0.104	0.607 *	0.886 ***	0.785 **	0.142	−0.119	0.028	−0.065	0.918 ***	0.163	0.137
M2	0.794 **	0.280	0.841 ***	0.695 *	0.654 *	0.086	0.033	−0.015	0.140	0.935 ***	0.193	0.315
M3	0.811 **	0.216	0.728 **	0.776 **	0.737 **	0.130	−0.021	−0.043	0.030	0.947 ***	0.223	0.341

* p < 0.05; ** p < 0.01; *** p < 0.001.