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. 2020 Dec 23;8(2):e001689. doi: 10.1136/jitc-2020-001689

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Prognostic value of soluble CD73 in subgroups of patients with metastatic melanoma receiving anti-PD-1 therapy alone. Groups of patients aged <65 years (A) or female (B) or with elevated serum lactate dehydrogenase (LDH) levels (C) or with BRAF mutations (D) or with bone metastases (E) or with brain metastases (F) and high CD73 activity (>38.8 pmol/min/mg protein) (red line) have worse overall survival compared with patients with low CD73 activity (<38.8 pmol/min/mg protein). P values were calculated using the log-rank test. ULN, upper limit of normal.