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. 2020 Dec 2;9(12):2579. doi: 10.3390/cells9122579

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Schematic representation of putative pathways linking age-related systemic and muscular iron dyshomeostasis, derangements in mitochondrial quality control, and systemic inflammation. Red callouts indicate mediators/processes that are mainly dysregulated. Abbreviations: DAMPs, damage-associated molecular patterns; Dcytb2, duodenal cytochrome b2; DMT1, divalent metal transporter 1; Fpn, ferroportin; IRP1/2, iron-responsive element-binding protein 1/2; PARL, presenilin-associated rhomboid-like protein; Pink1, phosphatase and tensin homolog-induced kinase 1; ROS, reactive oxygen species; SDR2, stromal cell-derived receptor 2; STEAP2, six-transmembrane epithelial antigen of the prostate 2; Tf, transferrin; TfR, transferrin receptor; TIM23, translocase of inner mitochondrial membrane 23; TOM, translocase of the outer mitochondrial membrane; ZIP14, Zrt-Irt-like protein 14.