Table 1.
Differentially regulated metabolites between samples from patients with pre- and post-operative colorectal cancer.
| Metabolites | Related Pathways | VIP | p-Value | Fold Change | Correlation Coefficient | Regulation |
|---|---|---|---|---|---|---|
| Gamma-aminobutyric acid | Arginine and proline metabolism | 1.0023 | <0.001 | 0.145828341 | 4.117358559 | Up |
| l-Proline | Arginine and proline metabolism | 1.71621 | <0.001 | 0.248728569 | 3.038287404 | Up |
| l-Threonine | Glycine, serine, and threonine metabolism | 4.84114 | <0.001 | −0.053349474 | 6.563445768 | Up |
| N4-Acetylaminobutanal | Lysine degradation | 1.62713 | <0.001 | 0.261500031 | 2.625861377 | Up |
| Unknown (m/z = 131.0643) | NA | 1.06877 | <0.001 | −0.080578542 | 6.860433801 | Up |
| Thymine | pyrimidine metabolism | 1.50327 | <0.001 | −0.37427256 | 1.606954027 | Up |
| Mevalonic acid | Terpenoid backbone biosynthesis | 1.01718 | <0.001 | −0.093645679 | 6.286436005 | Up |
| Xanthine | Purine metabolism | 1.00114 | <0.001 | 0.516947844 | 2.518903854 | Up |
| Unknown (m/z = 307.0758) | NA | 1.42141 | <0.001 | 0.423472971 | 7.681495389 | Up |
| Testosterone | Steroid hormone biosynthesis | 1.0227 | <0.001 | −0.181019259 | 0.467837133 | Down |
| Phytosphingosine | Sphingolipid metabolism | 1.02506 | <0.001 | 0.283161742 | 4.211946967 | Up |
| Dihydroceramide | Sphingolipid metabolism | 2.90611 | <0.001 | 0.089880246 | 0.05540464 | Down |
| Prostaglandin E2 | Arachidonic acid metabolism | 1.44895 | 0.001 | −0.052474587 | 46.02889156 | Up |
| 11β,21-Dihydroxy-5β-pregnane-3,20-dione | Steroid hormone biosynthesis | 1.02444 | 0.002 | −0.002157481 | 0.726773548 | Down |
| Chenodeoxycholic acid | Primary bile acid biosynthesis | 1.01772 | <0.001 | −0.197870962 | 31.81241423 | Up |
| Phosphoribosyl pyrophosphate | pyrimidine metabolism | 1.05047 | <0.001 | 0.039117952 | 0.084114079 | Down |
| Episterol | Steroid biosynthesis | 1.58977 | <0.001 | −0.01518394 | 65.07462767 | Up |
| Beta-Sitosterol | Steroid biosynthesis | 1.34755 | <0.001 | 0.548996098 | 2.874787603 | Up |
| 4α-Carboxy-4β-methyl-5α-cholesta-8,24-dien-3β-ol | Steroid biosynthesis | 1.08986 | <0.001 | 0.317512451 | 0.329377471 | Down |
| Leukotriene D4 | Arachidonic acid metabolism | 2.41915 | <0.001 | −0.017846652 | 85.53840187 | Up |
| Ceramide 1-phosphate | Sphingolipid metabolism | 1.03921 | <0.001 | −0.167097911 | 0.016887882 | Down |
| Androsterone glucuronide | Steroid hormone biosynthesis | 1.023 | <0.001 | −0.164779789 | 0.022209325 | Down |