Table 1.

List of registered clinical trials from 2014 to 2020.

Clinical Trial Number	MSC Origin	Title	Year of Registration
NCT02138331	Cord blood	Effect of Microvesicles and Exosomes Therapy on β-cell Mass in Type I Diabetes Mellitus (T1DM)	2014
Not found	Umbilical cord	Chronic kidney injury	2016
NCT03437759	Human umbilical cord	MSC-Exos Promote Healing of Macular holes MHs	2017
NCT03857841	Bone marrow	A Safety Study of IV Stem Cell-derived Extracellular Vesicles (UNEX-42) in Preterm Neonates at High Risk for Bronchopulmonary Dysplasia	2019
NCT04173650	Bone marrow	MSC EVs in Dystrophic Epidermolysis Bullosa	2020
NCT04223622	Adipose tissue	Effects of ASC Secretome on Human Osteochondral Explants (ASC-OA)	2020
NCT04313647	Bone marrow	A Tolerance Clinical Study on Aerosol Inhalation of MSC-EXO in Healthy Volunteers	2020
NCT04276987	Adipose Tissue	A Pilot Clinical Study on Inhalation of MSC-EXO Treating Severe Novel Coronavirus Pneumonia	2020
NCT04491240	Adipose Tissue	Evaluation of Safety and Efficiency of Method of Exosome Inhalation in SARS-CoV-2 Associated PneumoniaSARS-Cov2 pneumonia	2020
NCT04213248	Human umbilical cord	Effect of UMSCs Derived Exosomes on Dry Eye in Patients With cGVHD	2020
NCT04270006	Adipose tissue	Evaluation of Adipose Derived Stem Cells Exo in Treatment of Periodontitis	2020
NCT04134676	Wharton’s jelly	Therapeutic Potential of Stem Cell Conditioned Medium on Chronic Ulcer Wounds	2020
NCT04356300	Bone marrow	MSC-EXO for Multiple Organ Dysfunction Syndrome After Surgical Repair of Acute Type A Aortic Dissection	2020
NCT04544215	Adipose tissue	A Clinical Study of MSC-EXO Nebulizer for the Treatment of Pulmonary Infection	2020
NCT04388982	Adipose tissue	Safety and Efficacy Evaluation of Allogenic Adipose MSC-Exos in Patients with Alzheimer’s Disease	2020