Figure 1.

Single intraperitoneal injection of 6 mg/kg of oxaliplatin induced cold (a) and mechanical (b) allodynia in rats. The acetone and von Frey tests were used to assess cold and mechanical allodynia, respectively. Pre-injection: prior to the injection of oxaliplatin or 5% glucose (control). Post-injection: four days after the administration of oxaliplatin or 5% glucose. Control: n = 6, Oxaliplatin: n = 7. ns: Not significant, * p < 0.05, ** p < 0.01, vs. Control with two-way ANOVA followed by Sidak’s post-test for multiple comparisons.