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. 2020 Nov 24;12(12):737. doi: 10.3390/toxins12120737

Figure 4.

Figure 4

Single subcutaneous administration of bee venom acupuncture (BVA) at ST36 decreased cold (a,c) and mechanical (b,d) allodynia induced by oxaliplatin in rats. Cold and mechanical allodynia were assessed using acetone and von Frey tests, respectively. In all groups, behavioral assessments were conducted four days after the injection of 6 mg/kg of oxaliplatin (pre-injection), when significant allodynic signs were observed in rats and 30 min after the administration of phosphate-buffered saline (PBS) or 0.1 or 1 mg/kg of BVA or sham (brief syringe insertion) (post-injection). Control: n = 7, BV 0.1 mg/kg: n = 10, BV 1 mg/kg: n = 10 (a,b), Control: n = 6, Sham: n = 6, BV ST36: n = 6, BV LI11: n = 6 (c,d). * p < 0.05, ** p < 0.01, *** p < 0.001 vs. Control with two-way analysis of variance followed by Sidak’s post-test for multiple comparisons.