Table 2.
Identified targets of miR-378a-3p upon overexpression.
| Gene | Transcript ID | IP/T Ratio | miR-378a-3p Binding Site | Growth-Related GO |
||||
|---|---|---|---|---|---|---|---|---|
| EV * | 378a | FC | 5′UTR | CDS | 3′UTR | |||
| IRAK4 | ENST00000613694 | 1.0 | 4.6 | 4.6 | 8m | yes | ||
| CDKN2A | ENST00000304494 | 1.0 | 4.0 | 4.0 | yes | |||
| JPX | ENST00000415215 | 1.5 | 5.8 | 3.9 | 8m ** | |||
| PLGRKT | ENST00000223864 | 1.0 | 3.0 | 3.0 | 8m | |||
| TMEM245 | ENST00000374586 | 1.0 | 2.9 | 2.9 | 7m8/8m | |||
| TOMM6 | ENST00000398884 | 1.5 | 4.1 | 2.7 | ||||
| CDK1 | ENST00000395284 | 1.0 | 2.6 | 2.6 | yes | |||
| FAM117A | ENST00000240364 | 1.4 | 3.6 | 2.6 | ||||
| WDR83OS | ENST00000596731 | 1.3 | 3.2 | 2.5 | 7m8 | |||
| CCNK | ENST00000389879 | 1.0 | 2.4 | 2.4 | 8m | yes | ||
| MYCBP | ENST00000397572 | 2.3 | 5.4 | 2.3 | 7mA1 | |||
| RNF34 | ENST00000392465 | 1.3 | 3.0 | 2.3 | yes | |||
| UBC | ENST00000339647 | 1.0 | 2.3 | 2.3 | yes | |||
| POP4 | ENST00000585603 | 1.0 | 2.3 | 2.3 | ||||
| MNT | ENST00000174618 | 1.2 | 2.7 | 2.3 | 7m8 | 7mA1 | yes | |
| HSPB1 | ENST00000248553 | 1.8 | 3.9 | 2.2 | 7mA1 | yes | ||
| INAFM1 | ENST00000552360 | 1.3 | 2.8 | 2.2 | ||||
| PCNA | ENST00000379160 | 1.0 | 2.1 | 2.1 | yes | |||
| SP100 | ENST00000264052 | 1.2 | 2.5 | 2.1 | ||||
| RPP25L | ENST00000297613 | 1.2 | 2.4 | 2.0 | ||||
* IP/T ratios in pCDH-EV (EV) were set to 1.0 in cases where the ratios were <1.0. ** The binding site in the noncoding RNA is listed in the 3′-UTR column. 7mA1 = 7mer-A1, 7m8 = 7mer-m8, 8m = 8mer, FC = fold change, 378a = pCDH-378a, IP = Ago2 immunoprecipitated fraction, T = Total fraction, 5′UTR = 5′ untranslated region, CDS = coding sequence, 3′UTR = 3′ untranslated region, GO = gene ontology.