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. 2020 Nov 24;9(12):2539. doi: 10.3390/cells9122539

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Neurotransmitter stimulation mediated only moderate redox-responses in mitochondrial matrices. (A) Glutamate also induced biphasic redox-responses in the mitochondria. The initial reducing shift and the secondary oxidation of roGFPm did, however, not differ among genotypes. (B) Serotonin mediated a moderate oxidation of roGFPm, which was clearly more intense in Mecp2^−/y than in WT neurons. (C) Norepinephrine evoked only a very moderate oxidation of roGFPm, which was identical in both genotypes. (D) Dopamine mediated comparable oxidizing shifts in the mitochondrial matrix of WT and Mecp2^−/y neurons. (E) Summarizing bar plot of neurotransmitter-evoked changes in mitochondrial redox balance. (* p < 0.05; Mann–Whitney rank sum test). Plotted are the normalized changes in the roGFP ratio (ΔR/Ro), and the dot-plots signify the scatter of the underlying data.