Figure 2.

NLRP6 and IL-18 expressions in epithelial tumor cells are strong predictors of patients’ outcome. (A) NLRP6, caspase-1 and IL-18 were correlated with patients’ outcome in colorectal cancer. Survival curves of patients based on expression of inflammasome proteins in epithelial tumor cells are shown. Patients were stratified by high or low expressions according to cut-offs predetermined with ROC curves (NLRP6, caspase-1 and IL-18) or the median of fluorescence intensity (NLRP1, NLRP3, AIM2, ASC, IL-1B). Censored data are indicated by tick marks. Data for any patients who were not known to have died at the time of the analysis were censored at the last recorded date that the patient was known to be alive. 95%CI: 95% confidence interval; HR: Hazard Ratio. A log-rank test stratified according to protein expressions was used. NC: could not be calculated. (B) Stromal protein expression of NLRP6 and IL-18 were not correlated to survival. Survival curves of patients according to NLRP6 and IL-18 expression in stromal cells from colorectal tumors are shown. Patients were stratified according to the median fluorescence intensity for each marker, by high or low expression, according to cut-offs determined with ROC curves. Censored data are indicated by tick marks. Data for any patients who were not known to have died at the time of the analysis were censored at the last recorded date that the patient was known to be alive. 95%CI: 95% confidence interval; HR: Hazard Ratio. A log-rank test stratified according to protein expressions was used. NC: could not be calculated.