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Epithelial expression of NLRP6 and IL-18 are correlated with tumor evolution. For each protein, we assessed the correlation between fluorescence intensity and tumor stages, classified in stage I-II (locally advanced), stage III (regionally advanced) and stage IV (metastatic disease). A one-way ANOVA (parametric) or Kruskal-Wallis (unparametric) tests were used to evaluate the significance of the differential expression between each disease stage. * p < 0.05 and **** p < 0.0001.
