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. 2020 Nov 24;12(12):3500. doi: 10.3390/cancers12123500

Figure 4.

Figure 4

Expression of epithelial IL-18 is correlated with higher lymphocyte infiltration within colorectal tumors. For each protein, we assessed the correlation between fluorescence intensity of inflammasome component NLRP6 (A) or IL-18 (B) and immune infiltration assessed by immunohistochemistry for T cell lymphocytes (CD3+ and CD8+) and macrophages (CD68+ and CD163+). We also evaluated PD-1 and PD-L1 expressions. A one-way ANOVA (parametric) or a Kruskal-Wallis test (non-parametric) were used to evaluate the correlation between expression intensity and immune infiltrate levels. * p < 0.05 and ** p < 0.01.