Table 2.
Mean retinal layer thickness of optic neuritis eyes and healthy control eyes over time.
| Control (n = 48 Eyes) |
Optic Neuritis (n = 48 Eyes) | ||||
|---|---|---|---|---|---|
| Time1 1 | Time2 2 | Time3 3 | |||
| Less than 1 Month | 2–5 Months | 6–15 Months | p Value | ||
| TRL (μm) | 316.9 ± 12.5 | 307.8 ± 15.6 | 297.5 ± 15.5 | 291.4 ± 18.2 | |
| p value | 0.018 | <0.001 | <0.001 | <0.001 | |
| NFL (μm) | 28.5 ± 2.5 | 28.1 ± 4.5 | 23.3 ± 4.7 | 21.6 ± 5 | |
| p value | 1.000 | <0.001 | <0.001 | <0.001 | |
| GCL (μm) | 41.6 ± 2.8 | 36.4 ± 5.6 | 30.9 ± 7.2 | 29.5 ± 8 | |
| p value | <0.001 | <0.001 | 0.007 | <0.001 | |
| IPL (μm) | 75.9 ± 5 | 31.4 ± 4 | 28.2 ± 4.9 | 27 ± 5.1 | |
| p value | 0.002 | <0.001 | 0.014 | <0.001 | |
| INL (μm) | 34 ± 2.8 | 35 ± 3 | 35.1 ± 3.4 | 35.5 ± 3.2 | |
| p value | 1.000 | 1.000 | 1.000 | 0.471 | |
| OPL (μm) | 30.7 ± 4.2 | 29.9 ± 2.9 | 29.9 ± 3.2 | 29.8 ± 2.9 | |
| p value | 1.000 | 1.000 | 1.000 | 1.000 | |
| ONL (μm) | 65.3 ± 6.9 | 65.9 ± 9 | 67.5 ± 8.7 | 66.3 ± 8.1 | |
| p value | 1.000 | 0.054 | 0.017 | 0.007 | |
| ORL (μm) | 82.6 ± 2.3 | 81.3 ± 2.5 | 82.6 ± 2.3 | 82.2 ± 2.2 | |
| p value | 0.074 | 0.007 | 1.000 | 0.009 | |
Generalized estimating equation (GEE) analysis for changes in retinal layer thickness over time with adjustments for intra-subject inter-eye correlations, age, gender, and refractive errors. 1 Linear regression model using generalized estimating equations (GEE) analysis between control and time 1. The corrected p-values adjusted with Bonferroni’s correction (multiplied by 8) for each outcome are shown. 2 Linear regression model using GEE analysis between time periods 1 and 2. The corrected p-values adjusted with Bonferroni’s correction (multiplied by 24) for each outcome are shown. 3 Linear regression model using GEE analysis between time periods 2 and 3. The corrected p-values adjusted with Bonferroni’s correction (multiplied by 24) for each outcome are shown. TRL: total retinal layer; NFL: nerve fiber layer; GCL: ganglion cell layer; IPL: inner plexiform layer; INL: inner nuclear layer; OPL: outer plexiform layer; ONL: outer nuclear layer; ORL: outer retinal layer.