Table 6.
Association between OCT parameters at each time point and worse visual field outcomes (MD values of −10 dB or less) in ON eyes.
| Retinal Layer | Baseline | 2–5 Months | 6–18 Months | ||||
|---|---|---|---|---|---|---|---|
| OR (95% CI) | p-Value | OR (95% CI) | p-Value | OR (95% CI) | p-Value | ||
| TRL | Average | 0.96 (0.91, 1.01) | 0.395 | 0.92 (0.84, 1) | 0.168 | 0.92 (0.85, 0.99) | 0.077 |
| Superior | 0.97 (0.92, 1.02) | 0.606 | 0.93 (0.87, 1) | 0.114 | 0.93 (0.87, 0.99) | 0.051 | |
| Nasal | 0.97 (0.94, 1.01) | 0.388 | 0.94 (0.88, 1) | 0.112 | 0.93 (0.88, 0.99) | 0.047 | |
| Inferior | 0.96 (0.91, 1.01) | 0.232 | 0.92 (0.86, 0.99) | 0.057 | 0.92 (0.86, 0.98) | 0.024 | |
| Temporal | 0.96 (0.9, 1.01) | 0.414 | 0.93 (0.86, 1) | 0.115 | 0.93 (0.87, 0.99) | 0.073 | |
| NFL | Average | 0.88 (0.73, 1.06) | 0.506 | 0.78 (0.65, 0.93) | 0.019 | 0.7 (0.54, 0.91) | 0.022 |
| Superior | 0.93 (0.82, 1.05) | 0.659 | 0.84 (0.75, 0.95) | 0.013 | 0.76 (0.64, 0.91) | 0.007 | |
| Nasal | 0.96 (0.87, 1.07) | 1.000 | 0.85 (0.76, 0.96) | 0.027 | 0.78 (0.64, 0.94) | 0.029 | |
| Inferior | 0.88 (0.78, 0.99) | 0.107 | 0.82 (0.71, 0.96) | 0.036 | 0.76 (0.61, 0.94) | 0.039 | |
| Temporal | 0.61 (0.37, 0.99) | 0.141 | 0.61 (0.41, 0.9) | 0.037 | 0.6 (0.36, 0.97) | 0.116 | |
| GCL | Average | 0.85 (0.75, 0.97) | 0.054 | 0.79 (0.66, 0.94) | 0.023 | 0.76 (0.6, 0.95) | 0.042 |
| Superior | 0.9 (0.81, 1) | 0.122 | 0.85 (0.76, 0.96) | 0.022 | 0.81 (0.7, 0.94) | 0.014 | |
| Nasal | 0.87 (0.78, 0.97) | 0.043 | 0.8 (0.69, 0.94) | 0.016 | 0.8 (0.66, 0.96) | 0.054 | |
| Inferior | 0.84 (0.74, 0.94) | 0.007 | 0.77 (0.64, 0.93) | 0.018 | 0.74 (0.59, 0.92) | 0.024 | |
| Temporal | 0.89 (0.79, 1.01) | 0.193 | 0.83 (0.71, 0.96) | 0.045 | 0.79 (0.66, 0.95) | 0.039 | |
| IPL | Average | 0.79 (0.65, 0.97) | 0.066 | 0.69 (0.52, 0.91) | 0.024 | 0.67 (0.48, 0.93) | 0.054 |
| Superior | 0.82 (0.69, 0.99) | 0.111 | 0.69 (0.53, 0.9) | 0.019 | 0.71 (0.53, 0.95) | 0.059 | |
| Nasal | 0.84 (0.72, 0.98) | 0.081 | 0.75 (0.59, 0.94) | 0.040 | 0.71 (0.53, 0.95) | 0.064 | |
| Inferior | 0.77 (0.64, 0.92) | 0.010 | 0.66 (0.5, 0.88) | 0.013 | 0.64 (0.47, 0.88) | 0.016 | |
| Temporal | 0.8 (0.66, 0.99) | 0.106 | 0.74 (0.58, 0.94) | 0.037 | 0.71 (0.53, 0.94) | 0.056 | |
| INL | Average | 1.04 (0.8, 1.35) | 1.000 | 1.14 (0.91, 1.43) | 0.738 | 1.15 (0.93, 1.43) | 0.624 |
| Superior | 1.07 (0.89, 1.28) | 1.000 | 1.13 (0.98, 1.32) | 0.299 | 1.14 (0.98, 1.31) | 0.256 | |
| Nasal | 0.99 (0.81, 1.21) | 1.000 | 1.11 (0.95, 1.3) | 0.612 | 1.12 (0.97, 1.3) | 0.407 | |
| Inferior | 1.1 (0.86, 1.4) | 1.000 | 1.11 (0.88, 1.39) | 1.000 | 1.07 (0.85, 1.35) | 1.000 | |
| Temporal | 0.99 (0.77, 1.28) | 1.000 | 1.06 (0.84, 1.34) | 1.000 | 1.08 (0.87, 1.34) | 1.000 | |
| OPL | Average | 1.04 (0.87, 1.25) | 1.000 | 0.96 (0.82, 1.13) | 1.000 | 1.03 (0.86, 1.23) | 1.000 |
| Superior | 1.05 (0.95, 1.16) | 0.978 | 0.98 (0.9, 1.07) | 1.000 | 1.07 (0.95, 1.2) | 0.867 | |
| Nasal | 0.98 (0.86, 1.12) | 1.000 | 0.94 (0.83, 1.06) | 0.882 | 0.94 (0.83, 1.07) | 1.000 | |
| Inferior | 1.03 (0.89, 1.2) | 1.000 | 1.07 (0.96, 1.2) | 0.678 | 1.03 (0.93, 1.15) | 1.000 | |
| Temporal | 1.07 (0.91, 1.25) | 1.000 | 1.01 (0.86, 1.18) | 1.000 | 1.13 (0.91, 1.39) | 0.843 | |
| ONL | Average | 1.02 (0.95, 1.09) | 1.000 | 1.04 (0.98, 1.12) | 0.646 | 1.05 (0.98, 1.13) | 0.493 |
| Superior | 1.01 (0.95, 1.07) | 1.000 | 1.04 (0.98, 1.11) | 0.569 | 1.02 (0.96, 1.09) | 1.000 | |
| Nasal | 1.03 (0.97, 1.09) | 1.000 | 1.05 (0.98, 1.12) | 0.446 | 1.06 (0.99, 1.14) | 0.243 | |
| Inferior | 1.01 (0.95, 1.07) | 1.000 | 1.01 (0.95, 1.07) | 1.000 | 1.03 (0.96, 1.11) | 1.000 | |
| Temporal | 1.01 (0.95, 1.08) | 1.000 | 1.03 (0.97, 1.09) | 1.000 | 1.04 (0.97, 1.11) | 0.717 | |
| ORL | Average | 0.85 (0.61, 1.18) | 1.000 | 1.05 (0.8, 1.38) | 1.000 | 0.97 (0.72, 1.29) | 1.000 |
| Superior | 0.82 (0.64, 1.05) | 0.348 | 0.95 (0.73, 1.22) | 1.000 | 0.99 (0.76, 1.28) | 1.000 | |
| Nasal | 0.8 (0.57, 1.11) | 0.555 | 1.02 (0.83, 1.26) | 1.000 | 0.95 (0.73, 1.24) | 1.000 | |
| Inferior | 0.93 (0.7, 1.23) | 1.000 | 1.06 (0.84, 1.33) | 1.000 | 1 (0.78, 1.29) | 1.000 | |
| Temporal | 0.88 (0.68, 1.14) | 0.960 | 1.09 (0.82, 1.46) | 1.000 | 1.04 (0.77, 1.4) | 1.000 | |
Logistic regression analysis using the generalized estimating equation for the association between retinal layer thickness and visual field outcome with adjustments for intra-subject inter-eye correlations, age, gender, and refractive error. The corrected p-values adjusted with Bonferroni’s correction (multiplied by 3) for each outcome are shown. CI: confidence interval; OR: odds ratio; TRL: total retinal layer; NFL: nerve fiber layer; GCL: ganglion cell layer; IPL: inner plexiform layer; INL: inner nuclear layer; OPL: outer plexiform layer; ONL: outer nuclear layer; ORL: outer retinal layer.