Figure 3.

(a) Representative radiochromatograms of HPLC analysis (HPLC system 2b) of mice blood samples collected 5 min pi of [¹¹¹In]In-SG4, co-injected with vehicle (green line), LBQ657 (blue line) or co-injected with vehicle 30 min after oral administration of Entresto (red line). (b) Comparison of percent intact [¹¹¹In]In-SG4 across treatments (green, blue and red bars, respectively), showing statistically significant differences between LBQ657- or Entresto-treated mice vs. controls (**** p < 0.0001). Numerical average values ± SD are summarized in Table 1.