Figure 4.

Gnetin C reduces tumor growth in PC3M-Luc s.c. xenografts. (A) Male nude mice were injected s.c. with 10⁶ PC3M-Luc cells. Treatment (i.p.) with compounds started at day 19 when tumor volume was ~200 mm³. Tumor growth was measured using a digital caliper, twice a week. Significant tumor volume reduction was detected in all compound-treated vs. Ctrl group starting at day 25 with profound effect of Gnetin C at the high dose (50 mg/kg bw) at the endpoint. The mean ± SEM are shown. * p < 0.05; ** p < 0.01; **** p < 0.0001 (two-way ANOVA). (B) Representative images of two excised tumors from each treatment group are shown: Gnetin C in 50 mg/kg bw dose had firm inhibitory effect. (C) Average body weights of Ctrl and compound-treated groups during the study (n = 7/group).