Effect of cymoxanil on the kidneys. (A) Kidneys of rats treated with low and medium dose showing slight interstitial nephritis (triangle) with intertubular infiltration of mononuclear cells and degeneration of renal tubule epithelial lining (H&E, bar = 50 µm). (B) Kidneys of rats treated with high dose showing severe interstitial nephritis (triangle) and dilatation of the adjacent renal tubules (arrow) (H&E, bar = 100 µm). (C,D) Kidneys of rats treated with high dose showing thickening and sclerosis of the Bowman capsule and the surrounding renal tubules (arrows) (H&E and PAS respectively, bar = 50 µm). (E) Kidneys of control rats showing renal tubules with intact lining epithelium and glomeruli (H&E, bar = 50 µm).