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The intestinal crypt–villus structure and cell specification of intestinal stem cell (ISC)-differentiated intestinal epithelial cells (IECs) during homeostatic conditions (black arrow) and injury-induced cellular reprogramming (blue arrow). CBCs, crypt base columnar cells; TA, transit-amplifying cells; SPs, secretory precursors; ECs, enterocytes; GCs, goblet cells; PCs, Paneth cells; EECs, enteroendocrine cells.
