Table 1.
Demographics, baseline characteristics, and outcome.
| CytoSorb (n = 42) | Match (n = 42) | p | |
|---|---|---|---|
| n (%) or Median (IQR) | n (%) or Median (IQR) | ||
| Sex | |||
| Male | 27 (64.3) | 25 (59.5) | |
| Female | 15 (35.7) | 17 (40.5) | 0.823 |
| Age | 64 (48–73) | 68 (55–74) | 0.400 |
| Sepsis source | |||
| Abdominal | 15 (35.7) | 15 (35.7) | 1.000 |
| Pulmonal | 15 (35.7) | 14 (33.3) | 0.820 |
| Urogenital | 2 (4.8) | 4 (9.5) | 0.6760 |
| Soft tissue | 8 (19.0) | 8 (19.0) | 1.000 |
| Other | 9 (21.4) | 6 (14.3) | 0.569 |
| Suspected pathogen | 0.887 | ||
| Gram negative bacteria | 19 (45.2) | 18 (42.9) | |
| Gram positive bacteria | 17 (40.5) | 15 (35.7) | |
| Influenza | 2 (4.8) | 1 (2.4) | |
| Candida spp. | 1 (2.4) | 2 (4.8) | |
| Aspergillus spp. | 0 (0.0) | 1 (2.4) | |
| Unknown | 3 (7.1) | 6 (14.3) | |
| Comorbidities | 35 (83.3) | 37 (88.1) | 0.757 |
| Arterial hypertension | 32 (76.2) | 30 (71.4) | 0.804 |
| Cerebrovascular disease | 8 (19.0) | 10 (23.8) | 0.791 |
| COPD + | 4 (9.5) | 8 (19.0) | 0.350 |
| Coronary artery disease | 15 (35.7) | 16 (38.1) | 1.000 |
| Diabetes mellitus type 2 | 19 (45.2) | 14 (33.3) | 0.372 |
| Heart failure | 7 (16.7) | 7 (16.7) | 1.000 |
| Chronic kidney disease | 16 (38.1) | 14 (33.3) | 0.820 |
| Peripheral artery disease | 2 (4.8) | 7 (16.7) | 0.1560 |
| Total number of comorbidities | |||
| All | 2.5 (1.0–4.0) | 2.0 (0.3–4.0) | 0.9280 |
| Survivors | 1.0 (0.0–3.0) | 1.0 (0.0–3.3) | 0.9790 |
| Non-survivors | 4.0 (2.0–5.0) | 3.0 (2.0–4.8) | 0.5270 |
| Baseline values | |||
| SOFA score | 13.0 (12.0–14.75) | 12.0 (9.0–14.0) | 0.023 |
| PaO2/FiO2 [mmHg] | 160 (104–287) | 234 (126–294) | 0.095 |
| Norepinephrine [µg/kg/min] * | 0.52 (0.25–0.81) | 0.25 (0.05–0.54) | 0.014 |
| Bilirubin [mg/dL] | 1.18 (0.72–2.02) | 1.03 (0.78–1.76) | 0.747 |
| Thrombocytes [G/L] | 111 (70–172) | 106 (75–187) | 0.964 |
| Creatinine [mg/dL] | 1.84 (1.17–2.74) | 1.80 (1.29–2.69) | 0.758 |
| Leukocytes [G/L] | 13.95 (6.60–20.88) | 9.93 (6.11–15.26) | 0.304 |
| CRP [g/dl] | 13.64 (7.95–19.57) | 14.47 (10.40–24.25) | 0.508 |
| PCT [µg/L] | 15.53 (2.35–33.24) | 8.56 (2.05–38.60) | 0.567 |
| Lactate [mmol/L] | 3.5 (1.8–7.3) | 3.4 (2.0–5.3) | 0.687 |
| ICU LOS [d] | 21 (12–33) | 15 (8–26) | 0.121 |
| Hospital LOS [d] | 30 (17–49) | 30 (13–48) | 0.505 |
| 28d—mortality | |||
| Dead | 9 (21.4) | 20 (47.6) | 0.029 |
| alive | 33 (78.6) | 22 (52.4) | |
| In hospital mortality | |||
| Dead | 15 (35.7) | 26 (61.9) | |
| alive | 27 (64.3) | 16 (38.1) | 0.015 |
* displayed as norepinephrine equivalents (in accordance to [41]) within first hour; + Chronic obstructive pulmonary disease.