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Full factorial design (32) used for preparation and optimization of celecoxib in-situ provesicular powders.
| Independent Variables | Low | Mid | High |
|---|---|---|---|
| X1: Amount of Lipid | 200 | 400 | 600 |
| X2: Amount of Surfactant | 200 | 300 | 400 |
| Dependent Variables (Responses) | Desirability Constrains | ||
| Y1: Particle size (PS) | Minimize | ||
| Y2: Entrapment Efficiency (EE) % | Maximize | ||
