Table 2.
Distribution of normal PB leukocyte subsets in T/NK-LGLL according to their STAT3 or STAT5B mutational status.
| Cell Populations | Age-Matched HD (n = 628) |
T/NK-LGLL | p-Value | |
|---|---|---|---|---|
| Wild-Type STAT3 and STAT5B (n = 32) | STAT3 or STAT5B Mutated (n = 18) | |||
| Granulocytes (/µL) | 3977 (1678–8717) | 2503 (298–10,264) | 1308 (46–6676) | ≤0.008 abc |
| Neutrophils | 3709 (1563–8542) | 2301 (263–10,072) | 1217 (39–4974) | ≤0.01 abc |
| Eosinophils | 161 (0–876) | 143 (8.4–1402) | 30 (1.5–1250) | ≤0.03 abc |
| Basophils | 41 (2.2–222) | 51 (7.7–161) | 33 (4.3–452) | 0.02 a; 0.1 c |
| Monocytes (/µL) | 320 (66–1247) | 435 (23–1522) | 443 (150–1783) | 0.0001 a; 0.06 b |
| cMO | 419 (215–1063) | 400 (13–1426) | 366 (128–1778) | NS |
| ncMO | 67 (20–166) | 43 (0–225) | 40 (0.49–149) | ≤0.05 ab |
| Dendritic cells (/µL) | 24 (4.1–124) | 17 (0–54) | 8.2 (0.7–105) | ≤0.05 abc |
| Lymphocytes (/µL) | 1653 (0–5947) | 2084 (943–7547) | 1342 (553–4446) | 0.02 ac; 0.08 b |
| T lymphocytes (/µL) | 1188 (371–5298) | 1672 (655–6469) | 1109 (291–4039) | ≤0.05 ac |
| TCD8+ | 386 (13–2199) | 463 (0–3133) | 308 (38–2120) | NS |
| TCD4+ | 695 (106–3224) | 970 (88–3994) | 686 (227–2221) | ≤0.05 ac |
| Tαβ+DP | 8.6 (0–180) | 28 (2.2–341) | 24 (3.3–200) | ≤0.05 ab |
| Tαβ+DN | 15 (2–117) | 16 (2.2–94) | 13 (5.3–104) | NS |
| Tγδ+ | 47 (1–765) | 26 (0–598) | 17 (0–265) | 0.002 b; 0.06 c |
| NK cells (/µL) | 279 (0–1215) | 150 (2–1383) | 48 (0–408) | ≤0.006 abc |
| CD56−/+lo | 5.2 (1.1–19) | 2.6 (0–328) | 2.6 (0–44) | NS |
| CD56+ | 350 (116–773) | 144 (0–1372) | 30 (0–403) | ≤0.002 abc |
| CD56++ | 4.5 (1.4–25) | 7.8 (1.3–93) | 5.5 (0–46) | 0.08a |
| B lymphocytes (/µL) | 141 (8.1–867) | 177 (9.9–970) | 147 (15–409) | NS |
| Plasma cells (/µL) | 1.3 (0.104–14) | 1.2 (0.091–28) | 1.1 (0–14) | NS |
Results expressed as median (range) values. In bold: statistically significant differences (p-value ≤ 0.05). a HD vs. WT cases; b HD vs. STAT3/5B-mutated cases; c STAT3/5B-mutated vs. WT cases. Abbreviations (alphabetical order): HD, healthy donor; c, classical; LGLL, leukemia of large granular lymphocytes; MO, monocyte; nc, nonclassical; NS, no statistically significant differences (p-value > 0.05); PB, peripheral blood.