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Identification of TMZ resistance gene candidates and pathways as determined by CRISPR activation library screening. (A) Plot of enriched Human CRISPR activation library of individual sgRNA in the TMZ treated samples compared to vehicle (DMSO) samples determined by MAGeCK-VISPR tool analysis. (B) Pathway enrichment analysis, performed by Ingenuity software, of TMZ-enriched genes given by CRISPR activation library screening analysis.
