Table 1.
Top 25 CRISPRko library enriched sgRNA upon temozolomide (TMZ) treatment.
| sgRNA | Gene | Control_count | Treatment_count | FDR | Rank |
|---|---|---|---|---|---|
| HGLibA_56959 | PMS2 | 10.1/8.3 | 1644.2/1039.1 | 0 | 1 |
| HGLibA_29380 | MLH1 | 71.8/75.3 | 10,516.1/8493.7 | 0 | 2 |
| HGLibB_45493 | SLPI | 62.3/60.9 | 1612.5/22,063.1 | 3.3 × 10−283 | 3 |
| HGLibA_30203 | MSH6 | 145.4/314.7 | 21,025.1/17,627.1 | 1.5 × 10−135 | 4 |
| HGLibB_30160 | MSH6 | 56.9/51.6 | 4275.1/3345.3 | 1.8 × 10−154 | 5 |
| HGLibB_30150 | MSH2 | 109.2/147.5 | 8836.2/8593.6 | 4.6 × 10−100 | 6 |
| HGLibB_30148 | MSH2 | 40.9/5.2 | 963.5/914.5 | 5.1 × 10−240 | 7 |
| HGLibA_53112 | UQCRC1 | 22.5/14.4 | 1063.1/995.6 | 2.2 × 10−170 | 8 |
| HGLibB_53357 | USPL1 | 21.4/16.5 | 1051.1/997.9 | 6.3 × 10−153 | 9 |
| HGLibB_40798 | REPS1 | 31.5/3.1 | 471.9/531.3 | 3.0 × 10−172 | 10 |
| HGLibB_09799 | CLCA2 | 18.9/9.3 | 845.6/510.1 | 3.7 × 10−146 | 11 |
| HGLibB_37031 | PLEKHA6 | 49.3/2.1 | 391.1/577.1 | 5.7 × 10−144 | 12 |
| HGLibA_56902 | ZNF90 | 21.9/25.8 | 989.8/1188.4 | 5.5 × 10−95 | 13 |
| HGLibA_06820 | CA7 | 31.5/10.3 | 886.1/747.6 | 9.2 × 10−106 | 14 |
| HGLibA_29915 | MRPL18 | 10.7/55.7 | 1234.5/965.1 | 4.3 × 10−90 | 15 |
| HGLibA_14727 | EIF2AK2 | 25.5/13.4 | 746.2/778.1 | 1.6 × 10−86 | 16 |
| HGLibB_44264 | SLAMF7 | 238.1/408.7 | 13,929.1/11,287.1 | 1.3 × 10−21 | 17 |
| HGLibA_61495 | PER2 | 79.5/72.2 | 2574.1/3308.8 | 6.2 × 10−39 | 18 |
| HGLibA_00885 | ADAT3 | 16.6/13.4 | 729.8/405.5 | 4.6 × 10−74 | 19 |
| HGLibA_25835 | KRTAP9-3 | 22.5/29.9 | 1108.9/794.6 | 1.6 × 10−56 | 20 |
| HGLibA_60473 | PER1 | 42.1/18.5 | 1010.6/980.3 | 7.9 × 10−53 | 21 |
| HGLibA_20486 | GSTO1 | 30.3/6.2 | 512.4/444.3 | 8.1 × 10−70 | 22 |
| HGLibB_45186 | SLC51A | 26.1/29.9 | 867.4/1028.5 | 1.6 × 10−47 | 23 |
| HGLibA_36058 | PER2 | 33.3/21.7 | 1025.9/779.3 | 5.0 × 10−47 | 24 |
| HGLibA_05746 | C1orf111 | 22.5/25.8 | 773.5/795.7 | 5.1 × 10−47 | 25 |