Table 1.
Pharmacokinetic characteristics of sesquiterpene lactones and metabolites in serum over 24 h in 16 healthy adults after Brussels/witloof chicory consumption a.
| Compound | Cmax (nmol·L−1) | Tmax (h) | T1/2z (h) | AUC0–24 (nmol·h·L−1) |
|---|---|---|---|---|
| LAC-F | 142 ± 17.9 | 0.88 ± 0.12 | 2.13 ± 0.22 | 649 ± 84.3 |
| LAC-G | 19.8 ± 2.54 | 2.06 ± 0.14 | 2.80 ± 0.23 | 71.6 ± 10.8 |
| LAC-S | 16.3 ± 2.65 | 2.81 ± 0.31 | 4.14 ± 0.38 | 87.1 ± 14.5 |
| DLAC-F | 116 ± 19.5 | 0.78 ± 0.10 | 2.53 ± 0.22 | 563 ± 96.3 |
| DLAC-G | 22.1 ± 4.44 | 2.69 ± 0.30 | 3.17 ± 0.37 | 83.3 ± 15.2 |
| DLAC-S | 13.2 ± 2.17 | 2.38 ± 0.29 | 5.01 ± 0.55 | 67.1 ± 8.87 |
a Values are the means ± SEM, n = 16; LAC, lactucin; DLAC, 11β,13-dihydrolactucin; F, free; G, glucuronide; S, sulfate; Cmax, maximum serum concentrations; Tmax, time to achieve maximum serum concentrations; T1/2z, terminal elimination half-life; AUC0–24, the area under the concentration-time curve to 24 h.