Table 5.

Gene functional clusters of the 1000 highest ranked probes from linear regression analysis associated with membership of the ROLO intervention or control group.

	Pathway Type	Function	Count	p	Benjamini
Cluster 1: Insulin Functioning
ES: 1.91 *	KEGG	Insulin resistance	11	0.0023	0.17
	KEGG	AMPK signaling pathway	11	0.0055	0.21
	KEGG	Insulin signaling pathway	11	0.013	0.25
	KEGG	FoxO signaling pathway	8	0.14	0.56
Cluster 2: NOTCH Functioning
ES: 1.83 *	REACTOME	Constitutive signaling by NOTCH1 HD+PEST domain mutants	8	0.0017	0.25
	REACTOME	Constitutive signaling by NOTCH1 PEST domain mutants	8	0.0017	0.25
	REACTOME	NOTCH1 intracellular domain regulates transcription	6	0.014	0.65
	KEGG	Notch signaling pathway	6	0.018	0.29
	REACTOME	Notch-HLH transcription pathway	3	0.059	0.85
	REACTOME	Pre-NOTCH transcription and translation	3	0.22	0.98
Cluster 3: Cell Signal Functioning
ES: 1.31 *	REACTOME	PIP3 activates AKT signaling	8	0.012	0.71
	REACTOME	CD28 dependent PI3K/Akt signaling	4	0.029	0.77
	REACTOME	Constitutive signaling by AKT1 E17K in cancer	4	0.04	0.8
	REACTOME	VEGFR2 mediated vascular permeability	3	0.22	0.98

Clusters created using the DAVID (http://david.abcc.ncifcrf.gov/) Gene Functional Classification Tool and KEGG and REACTOME pathways. ES: enrichment score; Benjamini: Benjamini–Hochberg false discovery rate method; AKT: protein kinase B; AMPK: adenosine monophosphate-activated protein kinase; CD28: Cluster of Differentiation 28; PIP3: phosphatidylinositol-3,4,5-triphosphate; PI3K phosphatidylinositol 3-kinase; VEGFR2: Vascular endothelial growth factor receptor 2; (p-values ≤ 0.05). * Significant ES.