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. 2020 Nov 24;10(12):1593. doi: 10.3390/biom10121593

Figure 7.

Figure 7

EP3 and EP4 receptors participate in the MT-III-induced release of IL-6 and MCP-1, respectively, by 3T3-L1 preadipocytes. Cells were incubated with AH23848 (10 μM) or L-798106 (1 μM) or vehicle for 1 h followed by incubation with MT-III (0,4 μM) for 12 or 24 h. Graphs show participation of EP4 receptor in the MT-III-induced release of MCP-1 (A) and participation of the EP3 receptor in the MT-III-induced release of IL-6 (B). Concentration of cytokines were quantified from culture supernatants by Cytometric Bead Array (CBA). Results are expressed as mean ± SEM from 5 experiments. * p < 0.05 as compared with control group and # p < 0.05 as compared with MT-III group (one-way ANOVA and Bonferroni posttest).