Table 3.

Top molecular networks associated with human PON1-Q192R polymorphism. Upregulated (↑) and downregulated (↓) proteins are highlighted in bold red and green, respectively. Graphical illustrations of interactions between proteins in these networks are shown in Figure 5.

Analysis	Molecules in Network	Score	Focus Molecules	Top Diseases and Functions
PON1-192QQ vs. QR+RR (Figure 5A)	15-hydroxyeicosatetraenoic acid, 7-ketocholesterol, AMBP, APOA2, ascorbic acid, ↑C9, CD68, ↑CFP, Cu2, Fe2, ↓FETUB, FOS, GHRL, HDL, IL6, Immunoglobulin, ITIH1, ↑ITIH3, ITIH4, L-phenylalanine, LCAT, LDL, lipid peroxide, MSR1, palmitoleic acid, ↑PGLYRP2, ↓PLG, PLTP, ↓PON1, PON3, Rbp, ↓RBP4, TGFB1, ↓TTR, VLDL-cholesterol	27	9	Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry
PON1-192QQ vs. QR	15-hydroxyeicosatetraenoic acid, APCS, ↓APOA1, Apoc1, APOF, APOL1, ↓APOM, bilirubin, ↑C9, ↑CFP, Cxcl9, Fe2, Ferritin, ↓GPX3, Growth hormone, GSTT1, ↓HBB, HBD, HBG1, HBQ1, HDL, hemoglobin, ↓HPR, Immunoglobulin, Insulin, ITIH4, LDL, ↓PON1, PON3, Rbp, ↓RBP4, SAA2, SELENOT, ↓TTR, IGHV1-69, ↑IGLV3-9	28	11	Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry
PON1-192QQ vs. RR	15-hydroxyeicosatetraenoic acid, AFM, Alpha 1 antitripsin, AMBP, C1QTNF3, CCR2, CD40LG, Cd64, CD68, CXADR, ↓F13B, FCGR2C, Fe2, IFNG, IgG3 kappa, IgG3 lambda, IGHG1, ↑IGHG3, IGHG4, ITIH1, ↑ITIH3, ITIH4, LCAT, lipid peroxide, MSR1, MTRR, palmitoleic acid, ↓PON1, PON3, RAD51AP1, ↓RBP4, ↓SERPINA10, TGFB1, TNFAIP6, VLDL-cholesterol	18	6	Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry
PON1-192QR vs. RR (Figure 5B)	ALCAM, Alpha 1 antitrypsin, APOA2, APOA4, ↑APOD, Apolipoprotein, ↑APOM, arginine, C8G, C9, CD40LG, CLCN5, DUX4, F10, FAM20C, glutathione, glycosaminoglycan, GPX1, ↑GPX3, HDL, HMOX1, LCAT, LCN, NFE2L2, NFKBIA, NRG1, POU2F1, SEMA3F, ↓SERPINA10, SERPINC1, SREBF1, sulfatides, TFRC, UBQLN1, ↓VTN	14	5	Cardiovascular Disease, Neurological Disease, Organismal Injury and Abnormalities