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MRTFs and MYOF modulate proliferation and senescence upon DLC1 loss. Loss of the RhoGAP DLC1 results in Rho activation, which leads to actin polymerization, MRTF nuclear localization and expression of MRTF/SRF dependent target genes such as MYOF, resulting in enhanced HCC cell proliferation and migration. Depletion of MRTFs or MYOF inhibits HCC cell proliferation by inducing oncogene-induced senescence.
