. 2020 Nov 25;9(12):2540. doi: 10.3390/cells9122540

Table 2.

Drugs targeting senescence in HCC.

Strategy for Senescent Cell Elimination	Drug	Drug Target	References
SASP Inhibition	Rapamycin	mTor	[186,187]
	Sertraline	mTor	[188]
	Torin1	mTor	[189]
	Pacritinib	JAK2	[190]
	Ruxolitinib	JAK1/2	[191]
Senolytics	Dasatinib	Src kinase, BCR/Abl	[192,193]
	Quercetin	Bcl-xL	[192,193]
	A-1331852	Bcl-xL	[194]
	ABT-263, -737	Bcl-2, Bcl-xL and Bcl-W	[195]
	XL413	CDC7	[188]
	BETd	BRD4/NHEJ	[182]
	Ouabain (cardiac glycoside)	Na+/K+-ATPase	[196]
Immunotherapy	Poly(I:C)	NK cell activation	[197]
Immunotherapy	CAR-T	uPAR	[198]