Table A7.

Runtime for MICE-pmm and kNN-obs-sel imputations using different datasets.

Imputation Method	Dataset Sizes
	n = 599	n = 5400	n = 20,000
MICE-pmm (minutes)	1.9	13.4	138.9
kNN-obs-sel (minutes)	0.7	16.2	210.7

Imputation was applied to the actual NEO dataset (n = 599; 58% metabolites contain missing values) and two oversampled datasets generated from the NEO data. With n = 599, kNN-obs-sel was slightly faster. However, MICE-pmm imputation took a shorter time to complete the imputations in larger datasets.