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. 2020 Nov 28;11(12):1434. doi: 10.3390/genes11121434

Figure 5.

Figure 5

Interaction of four-point-one, ezrin, radixin, moesin (FERM) and src-homology 2 (SH2) domains of TYK2 with IFNAR1−α/β receptor alpha chain (IFNAR1). (A) 3D representation of the interaction of TYK2 FERM and SH2 domains with IFNAR1 (ID PDB: 4PO6). FERM domain is represented by subdomains (F1, F2, and F3) in red, SH2 domain in blue, and IFNAR1 in yellow; the sites of TYK2 R425 and S431 are represented with spheres in the protein structure and are indicated with black arrows. (B) Structural models from 0 to 50 ns of molecular dynamics (MD) of the TYK2–IFNAR1 complex, using the WT, R425H and S431G mutants. (C) Root mean square deviation (RMSD) and root mean square fluctuation (RMSF) of the TYK2 WT–IFNAR1, the TYK2 R425H–IFNAR1, and TYK2 S431G–IFNAR1 complexes. RMSD as a function of time (left) and RMSF vs. residues (right).