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Effects of F18 on UV-induced CPD (a) and 6-4PP formation (b) in 3D human reconstituted skin. The skin was treated with UV radiation (300 mJ/cm2) with or without free carvedilol (CAR) or F18 in two doses for 24 h. Genomic DNA was isolated from the skin and analyzed with slot blot assays. Quantified and normalized CPD and 6-4PP values are expressed as mean + SE (n = 3).
