Table 2.

Specific molecular targets identified for the different thyroid malignancies (FTA, FTC, CV-PTC, and FV-PTC). Proteins in bold were identified in more than one subtype.

FTA	CV-PTC	FV-PTC
AuNPs (n = 2)	AgNPs-FeNPs (n = 3)	AgNPs-AuNPs-FeNPs (n = 1)
AKR1C1, HNRNPCL2	ACSS3, GATM, ACADM	IGSF1
FTC	AuNPs-FeNPs (n = 4)	AuNPs-FeNPs (n = 7)
AgNPs-AuNPs-FeNPs (n = 4)	CISD1, UQCRFS1, HINT2, VDAC3	DBI, APOA2, DPYSL3, RPL3,
FABP3, FTH1, FTL, HKDC1		HNRNPUL2, PCSK2, PSMA5
AgNPs-AuNPs (n = 2)	AgNPs (n = 3)	AuNPs (n = 73)
DIABLO, SFXN1	SLC25A4, HNRNPCL2, KRT15	ADK, ARL8B, AHSG, NARS1, DARS1, DDX1, DDX39A, EPRS1, PRKAR2A, CD44, CLTA, COL14A1, MACROH2A2, CST3, ACO1, ARMT1, DDB1, DUOX2, DNM2, EIF2AK4, ECM1, CAPZB, FUBP3, FBP1, GPD2, GRHPR, GNA13, HSPA4, H2BU1, ITIH1, SSB, CYB5R1, HMGN1, PSIP1, DDX5, PDCD4, PDCD6, PSMA3, PSMA7, SEC31A, PSMD2, PSMD6, PSMD11, RPL26L1, RPL38, SRRM1, PPP1CB, SERPINB6, SERPINH1, U2AF2, SND1, Q99832, CCT3, CCT8, TXNDC5, TMSB4X, TWF1, UGP2, RAD23B, VARS1, GC, VWA1, ATP6V1A, PSMD12, ARHGDIA, PLS1, FLOT1, PSMA6, WARS1, LRRC47, EFHD2, RNPEP, DDAH1
AgNPs-FeNPs (n = 2)	AuNPs (n = 24)
H1-3, POSTN	ACOT13, AHCYL2, ATPAF2, CPT2, UQCR10, ALDH18A1, DNPH1, DSTN, HSD17B8, FBN2, LGALS1, GSTK1, GRPEL1, HDHD3, BDH2, HMGCL, RNASE10, NADK2, PLGRKT, FMC1, NIPSNAP3A, RPL11, SDHB, PROS1
AuNPs-FeNPs (n = 1)
ALDH4A1
AgNPs (n = 24)
ACOT13, SERPINC1 GOT1, ATP5ME, UQCRQ, NDUFA4 BDH1, ETFA, FH, TRAP1, HINT2 IDH3A, ACAA2, MTCH2, SLC25A11, MYL6B, NPC2, PPIF PCCA, ABHD11, PKLR, ALDH5A1 OXCT1, TUBB2B
	FeNPs (n = 29)
	ACOT1, SLC25A31, ALDH1B1, MT-ATP6, ATP5ME, ATP5MG, SLC25A13, C1QBP, CKB, UQCRB, UQCRQ, COX6B1, ECHS1, TRAP1, H2BC15, IGHA2, ALDH6A1, IMMT, ABHD10, PPIF, PCK2, ABHD11, YWHAH, PDHB, SUCLG2, SDHA, SOD2, YKT6, TFAM
AuNPs (n = 21)
ACTC1, NDUFAB1, CASP14, CNTNAP4, CKMT2, COX7A1, DUT GLUD2, GNB4, IGKV2D-28 IGKV3-11, KRT77, LAMP2, CD14 FDXR, PCCB, FAM162A, XP32 STOML2, THBS1, TPM2
FeNPs (n = 3)
IGKV3-15, IGKV3-20, TPP1		FeNPs (n = 10)
		ARF5, RPLP0P6, EIF5A2, H2AX, HYOU1, ILF3, ACAA2, SET, RPL12, WDR1