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. 2020 Nov 26;12(12):1144. doi: 10.3390/pharmaceutics12121144

Figure 7.

Figure 7

The anti-allodynic effects of topical (Hlin+)(cafa−) and its dose-response comparison to (Hlin+Cl−). (a) Topical (Hlin+)(cafa−) significantly relieves CRPS allodynia at w/w doses of 1.6% and 0.8% for as long as 120 min post-application (The shaded area represents PWT values from vehicle treated normal animals.) (** p < 0.01, *** p < 0.001 pre-versus post-drug PWT of 1.6% w/w (Hlin+)(cafa−); $$ p < 0.01, $$$ p < 0.001 that of 0.8% w/w and # p < 0.05 that of 0.4% w/w (n = 9)). (b) The dose–response curve of (Hlin+)(cafa−) reaches a higher peak and is shifted leftward as compared to (Hlin+Cl−), suggesting its greater efficacy and potency (red line depicits regression line). (c) Topical administration of Hcafa on its own exhibited no anti-allodynic effects.