Figure 3.

Overlap of protein-coding genes associated with differentially methylated CpGs in CGIs and promoter CGIs or at cardiac TFBS in promoters with cardiovascular-associated genes and known CHD genes. Known CHD genes are marked in bold. (A) Genes associated with DMCs of Twin1_TOF versus Twin1_H (i.e., Twin1) in CGIs or promoter CGIs. (B) Genes associated with DMCs of Twin2_TOF versus Twin2_H (i.e., Twin2) in CGIs or promoter CGIs. (C) Genes with DMCs of Twin1 at cardiac TFBS in their promoter. (D) Genes with DMCs of Twin2 at cardiac TFBS in their promoter. CGIs; CpG islands; CHD, congenital heart disease; DMCs, differentially methylated CpG sites; TFBS, transcription factor binding sites.