Figure 5.

Mycophenolate mofetil (MMF) reduced blood pressure and improved aortic endothelial function in deoxycorticosterone acetate (DOCA)-salt rats. (A) Time course of systolic blood pressure (SBP) measured by tail-cuff plethysmography. (B) Ratio of left ventricle/tibia length (mg/cm). (C) Endothelium-dependent relaxation induced by acetylcholine (ACh) in aortas precontracted by phenylephrine. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity (D) and in situ intracellular reactive oxygen species (ROS) (E) in aorta from all experimental groups. Values are expressed as mean ± SEM (n = 7–9). Scale bar (100 μm). ** p < 0.01 is significant differences compared with control (CTR). ## p < 0.01 is significant differences compared with untreated DOCA-salt group.