Figure 1.

Rodent tissue responses to Western-like diet. A 45% HFD provides a progressive development of tissue and whole-body changes consistent with the T2D-like phenotype. Using higher fat percentages may create a greater magnitude of tissue dysfunction or accelerate the process, resulting in missed opportunity to study key aspects of disease progression. Detailed tissue responses could be found in Table 1 through Table 5. High-fat diet (HFD), Type 2 Diabetes (T2D), Triacylglycerol (TAG) and Diacylglycerol (DAG).