Figure 5.

Anxiety levels induced by psychosocial stress correlate with cardiac dysfunction in Dsg2^mut/mut mice. No correlation was found between time spent in light with %LVEF from (a) WT mice and (b) Dsg2^mut/mut mice not subjected to RI (i.e., −PSS), or (c) WT mice after 14 days of RI challenge (i.e., +PSS). (d) Conversely, after 14 days of psychosocial stress, Dsg2^mut/mut mice showed a significant correlation between time spent in light and %LVEF (r = 0.83, p < 0.05). Data displayed in scatterplots; thick black lines represent the best linear fit through data; dotted lines represent two-tailed 95% confidence interval; text inset reports Spearman’s Rho values and associated p-values.