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Anchor-away (AA). The mechanism of anchor-away is based on the functional inhibition of the target protein. (A) Target protein is fused with the FKBP12-rapamycin-binding-domain of FKBP12-rapamycin-associated protein (FRAP) (FRB), while the anchor protein is fused with FKBP12. (B) Added rapamycin acts as a bridge between FRB and FKBP12, and POI is functionally inhibited by its own displacement from the physiological localization. POI: protein of interest. Ub: ubiquitin.
