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Nano-grad (NG). (A) Nano-grad contains VHL selective ligand, an anti-POI specific nanobody and arginine-rich tails for cellular permeabilization. (B) Heterobifunctional nano-grader molecules bring together the von Hippel–Lindau (VHL) E3 ligase complex and POI catalyzing proteasomal degradation of the target protein.
