Table 2.
Comparative univariate analyses for overall survival (OS), cancer-specific survival (CSS), disease-free survival (DFS)and bladder-recurrence-free survival (BRFS) in 1436 patients with UTUC.
| Univariate Analysis | OS | CSS | DFS | BRFS | ||||
|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | p-Value | HR (95% CI) | p-Value | HR (95% CI) | p-Value | HR (95% CI) | p-Value | |
| Age | <0.001 ** | 0.016 * | 0.007 ** | 0.696 | ||||
| <70 | 1 | 1 | 1 | 1 | ||||
| ≥70 | 1.595 (1.282, 1.985) | 1.401 (1.065, 1.843) | 1.325 (1.079, 1.627) | 1.043 (0.844, 1.288) | ||||
| Gender | 0.658 | 0.226 | 0.412 | <0.001 ** | ||||
| Male | 1 | 1 | 1 | 1 | ||||
| Female | 0.952 (0.765, 1.184) | 0.845 (0.643, 1.110) | 0.918 (0.748, 1.127) | 0.537 (0.435, 0.664) | ||||
| CAD | 0.030 * | 0.634 | 0.561 | 0.282 | ||||
| No | 1 | 1 | 1 | 1 | ||||
| Yes | 1.481 (1.038, 2.113) | 1.128 (0.687, 1.854) | 1.116 (0.771, 1.614) | 0.785 (0.505, 1.221) | ||||
| ESRD on dialysis | 0.036 * | 0.963 | 0.070 | 0.437 | ||||
| No | 1 | 1 | 1 | 1 | ||||
| Yes | 1.396 (1.022, 1.906) | 1.010 (0.649, 1.572) | 0.704 (0.482, 1.028) | 0.868 (0.606, 1.242) | ||||
| HTN | 0.069 | 0.974 | 0.637 | 0.164 | ||||
| No | 1 | 1 | 1 | 1 | ||||
| Yes | 1.224 (0.984, 1.522) | 1.005 (0.765, 1.320) | 0.952 (0.777, 1.167) | 1.161 (0.941, 1.434) | ||||
| DM | 0.010 * | 0.877 | 0.751 | 0.508 | ||||
| No | 1 | 1 | 1 | 1 | ||||
| Yes | 1.368 (1.077, 1.739) | 1.026 (0.743, 1.417) | 0.961 (0.752, 1.228) | 1.087 (0.849, 1.391) | ||||
| Non-UC malignancy | 0.012 * | 0.222 | 0.562 | 0.471 | ||||
| No | 1 | 1 | 1 | 1 | ||||
| Yes | 1.485 (1.090, 2.024) | 1.288 (0.859, 1.931) | 1.099 (0.799, 1.511) | 1.129 (0.812, 1.570) | ||||
| History of bladder tumor | 0.319 | 0.063 | 0.001 ** | <0.001 ** | ||||
| No | 1 | 1 | 1 | 1 | ||||
| Previous | 1.195 (0.750, 1.904) | 0.454 | 1.469 (0.850, 2.537) | 0.168 | 1.069 (0.664, 1.721) | 0.785 | 2.627 (1.836, 3.761) | <0.001 ** |
| Synchronous | 1.148 (0.841, 1.566) | 0.385 | 1.362 (0.941, 1.973) | 0.102 | 1.565 (1.202, 2.037) | 0.001 ** | 1.715 (1.305, 2.253) | <0.001 ** |
| Multiplicity | 0.035 * | 0.020 | <0.001 ** | 0.008 ** | ||||
| No | 1 | 1 | 1 | 1 | ||||
| Yes | 1.317 (1.020, 1.701) | 1.451 (1.061, 1.983) | 1.580 (1.255, 1.989) | 1.390 (1.091, 1.773) | ||||
| Grade | <0.001 ** | <0.001 ** | <0.001 ** | 0.072 | ||||
| G1 | 1 | 1 | 1 | 1 | ||||
| G2 | 1.472 (0.854, 2.539) | 0.164 | 1.689 (0.722, 3.951) | 0.227 | 3.016 (1.722, 5.282) | <0.001 ** | 0.989 (0.655, 1.493) | 0.957 |
| G3 | 2.170 (1.518, 3.101) | <0.001 ** | 3.700 (2.107, 6.497) | <0.001 ** | 3.838 (2.490, 5.914) | <0.001 ** | 0.801 (0.616, 1.041) | 0.097 |
| Pathological T stage | <0.001 ** | <0.001 ** | <0.001 ** | 0.770 | ||||
| pT0/Tis/pTa | 1 | 1 | 1 | 1 | ||||
| pT1 | 1.350 (0.897, 2.032) | 0.150 | 1.446 (0.714, 2.929) | 0.305 | 1.327 (0.840, 2.098) | 0.225 | 1.021 (0.753, 1.386) | 0.892 |
| pT2 | 1.753 (1.178, 2.610) | 0.006 ** | 3.321 (1.772, 6.222) | <0.001 ** | 2.699 (1.782, 4.086) | <0.001 ** | 1.262 (0.936, 1.703) | 0.128 |
| pT3 | 3.649 (2.558, 5.205) | <0.001 ** | 8.086 (4.533, 14.426) | <0.001 ** | 5.955 (4.081, 8.689) | <0.001 ** | 1.075 (0.798, 1.449) | 0.633 |
| pT4 | 9.121 (5.832, 14.264) | <0.001 ** | 23.668 (12.451, 44.988) | <0.001 ** | 13.882 (8.788, 21.930) | <0.001 ** | 0.176 (0.043, 0.717) | 0.015 * |
| Pathological N stage | <0.001 ** | <0.001 ** | <0.001 ** | 0.965 | ||||
| pN0 | 1 | 1 | 1 | 1 | ||||
| pNx | 1.405 (1.023, 1.931) | 0.036 * | 1.440 (0.956, 2.169) | 0.081 | 1.199 (0.906, 1.587) | 0.205 | 1.018 (0.780, 1.328) | 0.897 |
| pN+ | 5.439 (3.418, 8.654) | <0.001 ** | 8.158 (4.817, 13.818) | <0.001 ** | 6.088 (4.094, 9.054) | <0.001 ** | 0.966 (0.497, 1.877) | 0.918 |
| Histologic variant | <0.001 ** | <0.001 ** | <0.001 ** | 0.050 | ||||
| No | 1 | 1 | 1 | 1 | ||||
| Yes | 1.933 (1.419, 2.634) | 2.301 (1.599, 3.312) | 2.070 (1.550, 2.763) | 0.637 (0.406, 1.001) | ||||
| LVI | <0.001 ** | <0.001 ** | <0.001 ** | 0.125 | ||||
| No | 1 | 1 | 1 | 1 | ||||
| Yes | 2.166 (1.700, 2.759) | 2.966 (2.229, 3.947) | 2.769 (2.226, 3.444) | 0.788 (0.581, 1.069) | ||||
| Group | 0.124 | 0.185 | 0.064 | 0.001 ** | ||||
| Renal pelvis | 1 | 1 | 1 | 1 | ||||
| Ureter | 1.186 (0.954, 1.474) | 1.203 (0.915, 1.581) | 1.213 (0.989, 1.488) | 1.451 (1.176, 1.790) | ||||
CI, confidence; HR, hazard ratio; OS, overall survival; CSS, cancer-specific survival; DFS, disease-free survival; BRFS, bladder-recurrence-free survival * p < 0.05, ** p < 0.01.