Table 1.
Summary of chemokine receptors expressed by NK cells subpopulations and their respective ligands expressed by tumor or lymph nodes
Source of Chemokines | Chemokines | Chemokine Receptor | Chemokine Receptor Expression on the NK Cell Population | |
---|---|---|---|---|
NKbright | NKdim | |||
Tumor | CCL3, CCL5, CCL7, CCL9, CCL14-16, CCL23 | CCR1 | + | − |
CXCL1-3, CXCL5-8 | CXCR2 | − | ++ | |
CXCL9-11 | CXCR3 | ++ | − | |
CXCL12 | CXCR4 | + | ++ | |
CXCL8 | CXCR1 | − | ++ | |
CX3CL1 | CX3CR1 | − | ++ | |
CCL3, CCL4 | CCR5 | ++ | + | |
Lymph nodes | CCL19, CCL21 | CCR7 | ++ | − |
++ strong expression; + weak expression; − no expression.