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. 2020 Nov 30;9(12):1209. doi: 10.3390/antiox9121209

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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One day after a painful nerve root compression (NRC), withdrawal thresholds are significantly lower (i.e., more sensitive) than pre-injury baseline levels (day 0) regardless of whether they receive vehicle (* p < 0.0001) or SDG (** p < 0.0001) treatment. Withdrawal thresholds for the PBS vehicle group remain significantly lower (* p < 0.0001) than their baseline through day 7, while treatment with SDG significantly increases (^## p < 0.02) thresholds over vehicle as early as day 2, lasting until day 7. Thresholds after sham are significantly higher than both vehicle (^# p < 0.0004) and SDG(^{^} p < 0.0006) treatment at day 1 and significantly higher (# p < 0.016) than vehicle thresholds after day 1.