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. 2020 Nov 28;12(12):3560. doi: 10.3390/cancers12123560

Table 3.

Clinico-pathologic features of 49 young sporadic CRC patients between mutation carriers and non-mutation carriers. TNM: tumor size; lymphatic involvement and presence of metastases.

Features All Mutation Carriers Non-Mutation Carrier p Value
Patient No 49 6 43
Age 43.4 ± 5.7 43.7 ± 5.3 43.4 ± 5.8 0.906
Gender
Female 24 3 (13%) 21 (87%) 0.957
Male 25 3 (12%) 22 (88%)
Tumor TNM stage
1 8 0 (0%) 8 (100%) 0.237
2 10 1 (10%) 9 (90%)
3 21 2 (9.5%) 19 (90.5%)
4 10 3 (30%) 7 (70%)
Tumor Location
Right colon 10 3 (30%) 7 (70%) 0.055
Left colon and rectum 39 3 (7.7%) 36 (92.3%)
Tumor size
<5 cm 32 2 (6.3%) 30 (93.7%) 0.079
≥5 cm 17 4 (24%) 13 (76%)
Tumor histology
Adenocarcinoma 44 4 (9%) 40 (91%) 0.001
Mucinous 3 0 (0%) 3 (100%)
Signet ring cell 2 2 (100%) 0 (0%)
Tumor grade
Well 7 0 (0%) 7 (100%) 0.334
Moderate 34 4 (12%) 30 (88%)
Poor 8 2 (25%) 6 (75%)
Pre_operation CEA
<5 ng/mL 31 2 (6.5%) 29 (93.5%) 0.104
≥5 ng/mL 18 4 (22%) 14 (78%)
Recurrence (except TNM 4)
Yes 8 0 (0%) 8 (100%) 0.360
No 31 3 (10%) 28 (90%)