Table 3.
Biological activities of steroids derived from the genus Sinularia estimated by PASS.
| No. | Antitumor and Related Activity, (Pa) * | Lipid Metabolism Regulators, (Pa) * | Additional Biological Activity, (Pa) * |
|---|---|---|---|
| 37 | Antineoplastic (0.915) Proliferative diseases treatment (0.722) |
Anti-hypercholesterolemic (0.910) Lipid metabolism regulator (0.675) |
Autoimmune disorders treatment (0.889) Neuroprotector (0.700) |
| 38 | Antineoplastic (0.895) Proliferative diseases treatment (0.673) |
Anti-hypercholesterolemic (0.910) Atherosclerosis treatment (0.695) Lipid metabolism regulator (0.575) |
Autoimmune disorders treatment (0.874) Anti-inflammatory (0.717) Neuroprotector (0.700) |
| 39 | Antineoplastic (0.903) Proliferative diseases treatment (0.768) Dementia treatment (0.554) |
Anti-hypercholesterolemic (0.947) Lipid metabolism regulator (0.768) Hypolipemic (0.713) |
Autoimmune disorders treatment (0.829) Neuroprotector (0.835) Anti-inflammatory (0.786) |
| 40 | Apoptosis agonist (0.823) Antineoplastic (0.815) Proliferative diseases treatment (0.610) |
Hypolipemic (0.901) Anti-hypercholesterolemic (0.754) Atherosclerosis treatment (0.582) |
Antifungal (0.737) Anti-inflammatory (0.705) Antibacterial (0.597) |
| 41 | Apoptosis agonist (0.845) Antineoplastic (0.823) Proliferative diseases treatment (0.678) |
Hypolipemic (0.790) Anti-hypercholesterolemic (0.687) Atherosclerosis treatment (0.659) |
Anti-fungal (0.761) Anti-inflammatory (0.735) |
| 42 | Apoptosis agonist (0.851) Antineoplastic (0.824) Proliferative diseases treatment (0.739) |
Hypolipemic (0.769) Anti-hypercholesterolemic (0.733) Atherosclerosis treatment (0.631) |
Antifungal (0.783) Anti-inflammatory (0.775) Antibacterial (0.543) |
| 43 | Antineoplastic (0.890) Apoptosis agonist (0.743) Proliferative diseases treatment (0.551) |
Anti-hypercholesterolemic (0.793) Hypolipemic (0.767) Atherosclerosis treatment (0.638) |
Anti-inflammatory (0.728) Antifungal (0.725) Immunosuppressant (0.704) |
| 44 | Antineoplastic (0.841) Apoptosis agonist (0.770) Proliferative diseases treatment (0.760) |
Anti-hypercholesterolemic (0.900) Hypolipemic (0.843) Atherosclerosis treatment (0.620) |
Cardiotonic (0.872) Anesthetic general (0.847) Antifungal (0.787) |
| 45 | Antineoplastic (0.838) Proliferative diseases treatment (0.729) Antimetastatic (0.551) |
Anti-hypercholesterolemic (0.909) Hypolipemic (0.786) |
Antifungal (0.789) Anti-inflammatory (0.674) Cardiotonic (0.626) |
| 46 | Antineoplastic (0.665) Antimetastatic (0.626) |
Antiprotozoal (Plasmodium) (0.854) Antifungal (0.642) |
|
| 47 | Antineoplastic (0.790) Proliferative diseases treatment (0.652) |
Anti-hypercholesterolemic (0.963) Atherosclerosis treatment (0.742) |
Antifungal (0.798) Anti-inflammatory (0.722) |
| 48 | Proliferative diseases treatment (0.953) Anticarcinogenic (0.922) Antineoplastic (0.911) |
Anti-hypercholesterolemic (0.962) Hypolipemic (0.825) Atherosclerosis treatment (0.588) |
Neuroprotector (0.976) Antimycobacterial (0.929) Antifungal (0.885) |
| 49 | Chemopreventive (0.960) Proliferative diseases treatment (0.945) Anticarcinogenic (0.881) Antineoplastic (0.877) |
Anti-hypercholesterolemic (0.964) Hypolipemic (0.797) |
Antimycobacterial (0.936) Antifungal (0.847) Anti-inflammatory (0.823) Neuroprotector (0.757) |
| 50 | Chemopreventive (0.953) Proliferative diseases treatment (0.944) Antineoplastic (0.858) |
Anti-hypercholesterolemic (0.943) Hypolipemic (0.846) Atherosclerosis treatment (0.510) |
Respiratory analeptic (0.957) Neuroprotector (0.892) Antifungal (0.873) |
| 51 | Proliferative diseases treatment (0.976) Chemopreventive (0.959) Antineoplastic (0.906) Dementia treatment (0.631) |
Anti-hypercholesterolemic (0.976) Hypolipemic (0.735) Lipid metabolism regulator (0.707) |
Respiratory analeptic (0.992) Neuroprotector (0.953) Antifungal (0.838) Antiviral (Influenza) (0.653) |
| 52 | Antineoplastic (0.840) Apoptosis agonist (0.581) |
Hypolipemic (0.682) Cholesterol synthesis inhibitor (0.508) |
Immunosuppressant (0.671) Nootropic (0.548) |
| 53 | Antineoplastic (0.790) Proliferative diseases treatment (0.667) |
Anti-hypercholesterolemic (0.729) Cholesterol synthesis inhibitor (0.664) |
Anti-osteoporotic (0.965) Anti-eczematic (0.910) |
| 54 | Antineoplastic (0.790) Proliferative diseases treatment (0.767) |
Anti-hypercholesterolemic (0.729) Cholesterol synthesis inhibitor (0.614) |
Anti-osteoporotic (0.965) Anti-eczematic (0.910) |
| 55 | Antineoplastic (0.948) Alzheimer’s disease treatment (0.851) Apoptosis agonist (0.696) |
Anti-hypercholesterolemic (0.821) Neurodegenerative diseases treatment (0.815) Cholesterol synthesis inhibitor (0.741) |
Immunomodulator (HIV) (0.893) Antioxidant (0.821) |
| 56 | Chemopreventive (0.918) Proliferative diseases treatment (0.874) Antineoplastic (0.845) |
Anti-hypercholesterolemic (0.914) Acute neurologic disorders treatment (0.632) Atherosclerosis treatment (0.612) |
Anti-inflammatory (0.870) Immunosuppressant (0.818) |
| 57 | Antineoplastic (0.784) Apoptosis agonist (0.654) Prostate disorders treatment (0.625) |
Antiprotozoal (Plasmodium) (0.766) Anti-inflammatory (0.752) Immunosuppressant (0.705) |
|
| 58 | Antineoplastic (0.795) Apoptosis agonist (0.711) Prostate disorders treatment (0.633) |
Antiprotozoal (Plasmodium) (0.754) Anti-inflammatory (0.732) Immunosuppressant (0.712) |
* Only activities with Pa > 0.5 are shown.