Table 4.

Comparison between GastroPlus^® simulated and in-vivo observed furosemide pharmacokinetic parameters following p.o. drug administration.

40 mg p.o. Dose
Parameter	In-Vivo I a	In-Vivo II b	Predicted	PE(%) I	PE(%) II
Cmax (µg/mL)	0.61	0.75	0.71	−17.14	5.54
tmax (h)	1.5	1.12	1.36	9.33	−22.22
AUC0→∞ (µg∙h/mL)	2.13	2.44	3.66	−71.25	−50.06
AUC0→24 h (µg∙h/mL)	2.11	2.33	2.52	−19.25	−8.15
F (%)	NA	NA	52.2	NA	NA

^a Refers to the mean plasma profile from [43] (40 mg IR tablet); ^b refers to the mean plasma profile from [37] (40 mg IR tablet); NA, not available/not applicable.