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. 2020 Dec 2;12(12):2890. doi: 10.3390/polym12122890

Figure 2.

Figure 2

(A) Schematic illustration of photo-crosslinkable pH-responsive micelles based on poly(ethylene glycol)-poly(2,4,6-trimethoxybenzylidene-pentaerythritol carbonate-co-acryloyl carbonate) diblock copolymer. PTX-loaded crosslinked micelles exhibit superior extracellular stability while “actively” release PTX under a mildly acidic condition mimicking that of the endo/lysosomal compartments. (B) Size change of pH-sensitive crosslinked (CLM) and non-crosslinked (NCLM) micelles at various pH and 37 °C determined by dynamic light scattering measurements (DLS). (C) pH-dependent drug release from PTX-loaded crosslinked and non-crosslinked micelles at 37 °C. Reprinted with permission from ref [73]. Copyright 2012 Elsevier B.V.